• OPTOACOUSTIC IMAGING - Breast-cancer diagnostic tool can eliminate some physical biopsies

    by Jared Cobb | Dec 06, 2018
    • As Published in Laser Focus World

    Seno Medical evaluated and compared the stability of several different types of optical mounts as a function of temperature and vibration. They ultimately selected monolithic flexures from Siskiyou (Grants Pass, OR) since these provided an order-of-magnitude better stability over the next-best mounts in their tests.
    Siskiyou then worked with Seno to customize the exact form and fit needed for their Imagio system’s optomechanical arrangement.
    OPTOACOUSTIC IMAGING (Read More)



  • Optimizing Probe Positioning for Life Science Research

    by Jared Cobb | Nov 19, 2018
    As Published in BioPhotonics, Photonics Media
    Optomechanical probe positioners allow more comprehensive study of biological samples.
    This trending technology is playing a critical, unheralded role in life science research.
    The IS-OGP, a modular subassembly from Siskiyou, collimates light from an input single-mode fiber and directs it anywhere in the field of view of an upright microscope via a 45° beamsplitter. The light can be focused to an adjustable-diameter spot, the position of which is precisely located or scanned via mechanical (differential screw) or automated actuators.
    BioPhotonics 2018-11 Probe Positioning



  • Custom Optomechanics in Industrial UV Lasers

    by Jared Cobb | Nov 19, 2018
    As Published in Photonics & Imaging Technology
    In their latest generation of Q-switched, ultraviolet lasers, DPSS Lasers worked with
    Siskiyou to define a mechanism to perform this slow, repetitive motion.
    Photonics & Imaging Technology 2018-11 DPSS Laser Construction



  • Ultimately selected monolithic flexures from Siskiyou

    by Jared Cobb | Oct 25, 2018

    As Published in Laser Focus World
    “Waiting for a breast cancer diagnosis is extremely stressful for most patients. Unexpected system downtime, which might cancel or delay procedures, runs counter to our mission and simply cannot be tolerated,” says Lisa Bichsel, marketing director at Seno Medical. For this reason, the company evaluated and compared the stability of several different types of optical mounts as a function of temperature and vibration. They ultimately selected monolithic flexures from Siskiyou (Grants Pass, OR) since these provided an order-of-magnitude better stability over the next-best mounts in their tests.
    (read more...Laser Focus World 2018-10)

  • Industrial Laser Mount Eliminates Shifts During Shipping

    by | Dec 18, 2017

    As Published in Novus Light

    Lee Laser (now part of Coherent) built a successful business featuring lamp-pumped and then diode-pumped (i.e., DPSS) solid state lasers, with powers up to 100 watts.  In a field with multiple low-cost competitors, Lee Laser was able to effectively differentiate their brand as a supplier of affordable industrial lasers featuring “workhorse” reliability. Prior to the company’s acquisition by Coherent, Lee saw this brand image threatened when some of their side-pumped DPSS lasers failed to work to specification when received by the customer.  Because of the importance of reliability to their industrial customers and to Lee’s market leadership, the company set out to identify and eradicate the source(s) of these failures.  (read more ....)

  • Dodt gradient contrast microscopy | Published in BioPhotonics

    by Michael O'Coyne | Dec 07, 2017
    48220000Imaging transparent, colorless specimens has always presented a challenge in optical microscopy. In many applications, it is not desirable or even possible to use fluorescent dyes, stains or transgenic probes to render target objects more visible.  While differential image contrast (DIC), often in the form of the Nomarski microscope, is widely employed, its optical complexity can cause limitations when the contrast image is combined with some other measurement modality or imaging technique (such as patch-clamp measurements or optogenetic stimulation, or even simply epi-fluorescence)..... Biophotonics 2017-11 Microscopy

  • Neuroscience Under the Microscope | Published Article from Novus Light

    by Michael O'Coyne | Aug 15, 2017

    NovusLight-figure-1While optical microscopy methods for neuroscience have expanded significantly in recent times, traditional tools such as patch clamp technology are still widely used because they provide superior data for many types of experiments. Researchers at the AstraZeneca-Tufts Laboratory for Basic and Translational Research are using patch clamp technology to study fundamental aspects of synaptic inhibition that are associated with epileptic-type seizures. This Institute itself is an exciting new business model in the world of neuroscience research, created as a joint collaborative venture between a leading academic institution and a highly respected pharmaceutical giant. (read more .....)

  • Siskiyou Appoints eQuestus as U.S. Western Regional Representative

    by Michael O'Coyne | Feb 27, 2017
    Siskiyou Corporation has appointed eQuestus Corp. as their exclusive sales representative for the western United States (AZ, CO, ID, MT, NV, NM, OR, UT, WA, WY, CA, NV and UT).  (read more....)
  • Modular Accessories Expand, Published in BioPhotonics

    by Michael O'Coyne | Feb 27, 2017
    Modular Accessories Expand; Fluorescence Microscope Capabilities.
    From neuroscience to morphogenesis and photosynthesis, optomechanical modules allow researchers to utilize fluorescence microscopy in diverse and increasingly complex studies.
    (read more ....)



  • Press Release, as seen at electrooptics.com

    by Michael O'Coyne | Oct 06, 2016
    Components for customising microscopes.  Siskiyou now offers a set of interchangeable modules and accessories for customising the
    functionality of optical microscopes from all major manufacturers (Zeiss, Nikon, Olympus), or even for building a new microscope. (read more...)


  • Ultra-stable micromanipulators, as seen in Laser Focus World

    by Michael O'Coyne | Oct 04, 2016
    Among the DC/servo options, the MX7000 series demonstrated the lowest amount of play and drift compatible with MyoStretcher’s target performance (measurement to 1 nN), while providing up to 20 mm of motion in each axis. A motorized actuator with anti-backlash gear-head (in each axis), driving a crossed roller-bearing highly linear stage, eliminates axial and lateral play, and a pre-loaded screw drive avoids the possibility of drift when stationary—that is, during a typical single myocyte experiment. Also, because the three-axis subsystems were originally developed for demanding electrophysiology (patch clamp) experiments, they are totally compatible with the limited access of a high-magnification optical microscope.  (read more...)

  • OEM Integration of the IXF1.0i, Published in Laser Focus World

    by Michael O'Coyne | Jun 15, 2016
    High-stability flexure mounts were crucial to Opotek’s miniaturized, shippable OPO with its shipping-based technical support model (a). Thermal stability (averaged over both x and y-axes) is shown for a Siskiyou IXF1.0i monolithic flexure mount and high-stability kinematic mounts from two other manufacturers (b). Thermal performance data for the latter two are from manufacturers’ published literature. (read more...)

  • Press Release, as seen on Photonics.com

    by Michael O'Coyne | May 02, 2016
    GRANTS PASS, Ore., April 25, 2016 — The 50.5cr crossed roller stages from Siskiyou Corp. are designed for space- or weight-constrained applications. The stages feature a non influencing foil lock mechanism, and offer a linear travel range of 12 mm and 33 × 33-mm mounting platform. 
    The stages are compatible with both manual and motorized actuators from Siskiyou, including 80 TPI and 100 TPI pitch screws, an ultrahigh resolution differential micrometer, and the company’s 512 series motorized actuators.  Applications include microscopy, intracavity adjustments in laser, and medical device incorporation. (read more ....)


  • Published Article from Novus Light

    by Michael O'Coyne | Mar 08, 2016
    After decades of promise and hype, but very limited market uptake, laser systems for dentistry are finally taking off.  One of the leading products is the Solea from Convergent Dental, which provides a superior alternative to the mechanical drill, plus the flexibility of several soft tissue procedures, including wound sealing, and even cutting/ osseous tissue (bone).  This article reviews the development of this system, including the use of novel optomechanics from Siskiyou Corporation to simplify system assembly, improve stability and reduce cost. (read more ....)

  • Published Article from BioPhotonics

    by Michael O'Coyne | Oct 14, 2015

    Comparing Micromanipulators for Electrophysiology

    Several different technologies offer a range of performance options within the confines of an optical microscope for patch-clamp studies, intracellular recording and other demanding experiments in electrophysiology. (read more ....)

  • Published Article from BioOptics

    by Michael O'Coyne | Oct 14, 2015

    Boosting conventional microscopes for optogenetics

    A simple, modular optomechanical tool breaks barriers by enabling the seamless addition and control of a secondary light source in standard microscopy setups. The cost-efficient tool facilitates not only photoactivation for optogenetics, but also extends microscope imaging capabilities. (read more ....)

  • Press Release, Dual-Wavelength Excitation Light Source

    by Michael O'Coyne | Sep 15, 2015
    GRANTS PASS, Ore., Sept. 15, 2015 — Suitable for both end users and OEMs, a dual-wavelength excitation light source from Siskiyou Corp. may be used in optongenetics and other life sciences applications.  The IS-LEDc combines the output from two LEDs (read more....)


  • Siskiyou Solves Thermal Issues Associated with Flow Cytometry Miniaturization

    by Michael O'Coyne | Aug 25, 2015

    GRANTS PASS, Or., Aug. 17, 2015 - Although product miniaturization can confer numerous practical advantages, it may create significant design issues - hurdles that need to be overcome to make the miniaturization a reality. Siskiyou Corp., a supplier of positioning equipment for life sciences and which specializes in building hardware for space- and access-restricted applications, has just solved such an obstacle. (read more....)

  • Article for Photonics Spectra - Delivering Superior Mounting Precision

    by Michael O'Coyne | May 20, 2015

    Optical mounts frequently play a critical role in overall laser system performance. Yet their impact often becomes obvious only when system operation degrades due to optical misalignment induced by vibration, thermal drift or long term mechanical creep in mounts. This article reviews basic styles of optical mount design and construction, and compares various mount types in terms of their stability, functionality and cost. (Read More ....)

  • Published Article from BioPhotonics - Comparing Micromanipulators for Electrophysiology

    by Michael O'Coyne | May 20, 2015

    Electrophysiology encompasses the measurement and analysis of transient ion flows and resultant voltage changes across cellular membranes, e.g., sodium ion channels that enable nerve cell signal transmission.  A key, but often unheralded, component of these experiments is the micromanipulation system used by the researcher to maneuver the micropipettes (Read More....)